Dynamics of lymphatic regeneration and flow patterns after lymph node dissection.
Identifieur interne : 003700 ( Main/Exploration ); précédent : 003699; suivant : 003701Dynamics of lymphatic regeneration and flow patterns after lymph node dissection.
Auteurs : Katrin S. Blum [Suisse] ; Steven T. Proulx ; Paola Luciani ; Jean-Christophe Leroux ; Michael DetmarSource :
- Breast cancer research and treatment [ 1573-7217 ] ; 2013.
Descripteurs français
- KwdFr :
- MESH :
- effets indésirables : Biopsie de noeud lymphatique sentinelle, Lymphadénectomie.
- physiopathologie : Système lymphatique.
- Animaux, Lymphoedème, Mâle, Souris, Système lymphatique.
English descriptors
- KwdEn :
- MESH :
- adverse effects : Lymph Node Excision, Sentinel Lymph Node Biopsy.
- physiopathology : Lymphatic System.
- prevention & control : Lymphedema.
- surgery : Lymphatic System.
- Animals, Male, Mice.
Abstract
Knowledge about the mechanisms of regeneration of the lymphatic vasculature after surgical trauma is essential for the development of strategies for the prevention and therapy of lymphedema. However, little is known about the alterations of lymphatic flow directly after surgical trauma. We investigated lymphatic function in mice using near-infrared imaging for a period of 4 weeks after surgeries that mimic sentinel lymph node biopsy (SLNB) or axillary lymph node dissection (ALND), by removal of the popliteal lymph node (LN) alone or together with the popliteal fat pad, respectively. SLNB-like surgery did not cause changes in lymphatic drainage in the majority of cases. In contrast, lymphatic drainage impairment shown by collecting vessel rupture, dermal backflow and rerouting of lymph flow via collateral vessels were observed after ALND-like surgery. All collateral vessels drained to the inguinal LN. These results indicate that less invasive surgery prevents lymphatic decompensation. They also reveal the development and maturation of collateral lymphatic vessels after extensive surgical trauma, which reroute the flow of lymph towards a different LN. These findings might be helpful for the development of strategies to prevent and/or treat post-surgical lymphedema.
DOI: 10.1007/s10549-013-2537-7
PubMed: 23613202
Affiliations:
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Proulx</name></author><author><name sortKey="Luciani, Paola" sort="Luciani, Paola" uniqKey="Luciani P" first="Paola" last="Luciani">Paola Luciani</name></author><author><name sortKey="Leroux, Jean Christophe" sort="Leroux, Jean Christophe" uniqKey="Leroux J" first="Jean-Christophe" last="Leroux">Jean-Christophe Leroux</name></author><author><name sortKey="Detmar, Michael" sort="Detmar, Michael" uniqKey="Detmar M" first="Michael" last="Detmar">Michael Detmar</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2013">2013</date><idno type="RBID">pubmed:23613202</idno><idno type="pmid">23613202</idno><idno type="doi">10.1007/s10549-013-2537-7</idno><idno type="wicri:Area/PubMed/Corpus">001B80</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001B80</idno><idno type="wicri:Area/PubMed/Curation">001B80</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001B80</idno><idno type="wicri:Area/PubMed/Checkpoint">001B80</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001B80</idno><idno type="wicri:Area/Ncbi/Merge">005854</idno><idno type="wicri:Area/Ncbi/Curation">005854</idno><idno type="wicri:Area/Ncbi/Checkpoint">005854</idno><idno type="wicri:Area/Main/Merge">003707</idno><idno type="wicri:Area/Main/Curation">003700</idno><idno type="wicri:Area/Main/Exploration">003700</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Dynamics of lymphatic regeneration and flow patterns after lymph node dissection.</title><author><name sortKey="Blum, Katrin S" sort="Blum, Katrin S" uniqKey="Blum K" first="Katrin S" last="Blum">Katrin S. Blum</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, Wolfgang Pauli-Str. 10, HCI H303, 8093, Zurich, Switzerland. blum.katrin@gmx.de</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, ETH Zurich, Wolfgang Pauli-Str. 10, HCI H303, 8093, Zurich</wicri:regionArea><wicri:noRegion>Zurich</wicri:noRegion></affiliation></author><author><name sortKey="Proulx, Steven T" sort="Proulx, Steven T" uniqKey="Proulx S" first="Steven T" last="Proulx">Steven T. Proulx</name></author><author><name sortKey="Luciani, Paola" sort="Luciani, Paola" uniqKey="Luciani P" first="Paola" last="Luciani">Paola Luciani</name></author><author><name sortKey="Leroux, Jean Christophe" sort="Leroux, Jean Christophe" uniqKey="Leroux J" first="Jean-Christophe" last="Leroux">Jean-Christophe Leroux</name></author><author><name sortKey="Detmar, Michael" sort="Detmar, Michael" uniqKey="Detmar M" first="Michael" last="Detmar">Michael Detmar</name></author></analytic><series><title level="j">Breast cancer research and treatment</title><idno type="eISSN">1573-7217</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Lymph Node Excision (adverse effects)</term><term>Lymphatic System (physiopathology)</term><term>Lymphatic System (surgery)</term><term>Lymphedema (prevention & control)</term><term>Male</term><term>Mice</term><term>Sentinel Lymph Node Biopsy (adverse effects)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Biopsie de noeud lymphatique sentinelle (effets indésirables)</term><term>Lymphadénectomie (effets indésirables)</term><term>Lymphoedème ()</term><term>Mâle</term><term>Souris</term><term>Système lymphatique ()</term><term>Système lymphatique (physiopathologie)</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Lymph Node Excision</term><term>Sentinel Lymph Node Biopsy</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Biopsie de noeud lymphatique sentinelle</term><term>Lymphadénectomie</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Système lymphatique</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Lymphatic System</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Lymphatic System</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Male</term><term>Mice</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Lymphoedème</term><term>Mâle</term><term>Souris</term><term>Système lymphatique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Knowledge about the mechanisms of regeneration of the lymphatic vasculature after surgical trauma is essential for the development of strategies for the prevention and therapy of lymphedema. However, little is known about the alterations of lymphatic flow directly after surgical trauma. We investigated lymphatic function in mice using near-infrared imaging for a period of 4 weeks after surgeries that mimic sentinel lymph node biopsy (SLNB) or axillary lymph node dissection (ALND), by removal of the popliteal lymph node (LN) alone or together with the popliteal fat pad, respectively. SLNB-like surgery did not cause changes in lymphatic drainage in the majority of cases. In contrast, lymphatic drainage impairment shown by collecting vessel rupture, dermal backflow and rerouting of lymph flow via collateral vessels were observed after ALND-like surgery. All collateral vessels drained to the inguinal LN. These results indicate that less invasive surgery prevents lymphatic decompensation. They also reveal the development and maturation of collateral lymphatic vessels after extensive surgical trauma, which reroute the flow of lymph towards a different LN. These findings might be helpful for the development of strategies to prevent and/or treat post-surgical lymphedema.</div></front></TEI><affiliations><list><country><li>Suisse</li></country></list><tree><noCountry><name sortKey="Detmar, Michael" sort="Detmar, Michael" uniqKey="Detmar M" first="Michael" last="Detmar">Michael Detmar</name><name sortKey="Leroux, Jean Christophe" sort="Leroux, Jean Christophe" uniqKey="Leroux J" first="Jean-Christophe" last="Leroux">Jean-Christophe Leroux</name><name sortKey="Luciani, Paola" sort="Luciani, Paola" uniqKey="Luciani P" first="Paola" last="Luciani">Paola Luciani</name><name sortKey="Proulx, Steven T" sort="Proulx, Steven T" uniqKey="Proulx S" first="Steven T" last="Proulx">Steven T. Proulx</name></noCountry><country name="Suisse"><noRegion><name sortKey="Blum, Katrin S" sort="Blum, Katrin S" uniqKey="Blum K" first="Katrin S" last="Blum">Katrin S. 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